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TABLE 1 Promising natural active ingredient for regulating ferroptosis

No effect was seen in the high-dose group (striped bars)

doi: 10.3389/fimmu.2020.598877 162 AlfaroCSuarezNGonzalezASolanoSErroLDubrotJet al

This surge correlates with increasing awareness of coppers role in suppressing NF-kB pathways, which reduces cytokine-driven inflammation by up to 41% in clinical models

It reduces the activity of tyrosinase by three different mechanisms: (i) chelation of the copper site by its thiol group, (ii) interfering with the cellular transfer of tyrosinase to premelanosomes which is a prerequisite for melanin synthesis, and (iii) indirectly via its antioxidant effect.[] Glutathione shifts melanogenesis from eumelanin to phaeomelanin synthesis by reactions between thiol groups and dopa-quinone leading to the formation of sulfhydryl-dopa conjugates.[] It has also been found to be scavenger of UV radiation-induced reactive oxygen species generated in epidermal cells.[] METHODS This was a prospective comparative study to assess and compare the therapeutic efficacy of localized TA and glutathione for treatment of facial melasma over a period of 18 months (December 2017 to May 2019) conducted in department of dermatology on OPD basis in a tertiary care center