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Regulatory Status: In the U.S., OTC skin lighteners are regulated as cosmetics unless they claim to treat disease

In collagen lab studies, higher concentrations drove more collagen synthesis, so serums built around centella tend to feature it more prominently

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De Vries FT, Hoffland E, Van Eekeren N, Brussaard L, Bloem J

Beta-3 Adrenergic Receptor (3-AR) Pathway Activation The primary documented mechanism of AOD-9604 in laboratory research models is activation of the beta-3 adrenergic receptor (3-AR), a G-protein-coupled receptor expressed predominantly in adipose tissue