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2013), the vast majority of potential Nrf2 modulators are electrophiles with an inherent propensity to interact with off-target cellular nucleophiles

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Gupta SC, Patchva S, Aggarwal BB

The 2,3DPG functions to control the affinity of haemoglobin for oxygen and NADPH is a major source of the reducing equivalents needed to protect haemoglobin against oxidative injury

Implication of trimethylamine N-oxide (TMAO) in disease: potential biomarker or new therapeutic target