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The substance is documented in a monograph under the United States Pharmacopeia (USP) or the National Formulary (NF)

The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity

4.7 Catalase Catalase is a haem-containing enzyme that catalyses the decomposition of H 2 O 2 into water and molecular oxygen

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[DOI] [PubMed] [Google Scholar] Amali M