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Epub 2017 Jun 8

PMID:33396470;PMCID:PMC7795577

Together, these results indicate that the abundance of mitochondrial CI is regulated by the circadian clock independently of direct transcriptional control

This dual-pathway architecture ghrelin-receptor agonists like ipamorelin acting through calcium/IP3 signaling, versus GHRH analogs acting through cAMP has made ipamorelin a frequently used research tool for studying how these two pituitary signaling pathways interact and, in some study designs, potentiate one another