Allergic/ Immune Reactions: Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylaxis, allergic myocarditis, erythema multiforme, exfoliative dermatitis, angioedema, drug fever, chills, Henoch-Schenlein purpura, serum sickness-like syndrome, generalized allergic reactions, generalized skin eruptions, photosensitivity, conjunctival and scleral injection, pruritus, urticaria, rash, periarteritis nodosa, hemophagocytic lymphohistiocytosis (HLH), systemic lupus erythematosus, drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized erythematous pustulosis (AGEP), and acute febrile neutrophilic dermatosis (AFND) (see WARNINGS)
In addition, facial sallowness was assessed visually by trained evaluators using a 09 severity scale with 0.5-point increments: 0 = no visible sallowness
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Specifically, single-target drugs are often limited by insufficient efficacy, rapid development of resistance, and significant side effects (Han Li and Chen, 2015
So, where should you begin