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One trial included healthy non-obese participants, demonstrating that the favorable safety profile was not unique to obese individuals

Neuropathy or neurological disease: Although evidence is mixed, injections are often given when deficiency is linked to nerve pain or cognitive symptoms

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For maintenance or prophylactic use (such as in a patient with short-gut syndrome who cannot absorb oral vitamins well), a common regimen is 1 mL IM once weekly