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Certain medications, including some medications used to treat gastrointestinal disorders, may make it more difficult for some people to absorb B12 from food sources

I was diagnosed a decade ago with pernicious anemia

Of relevance, recent evidence indicates that SAM exerts anti-inflammatory effects by reducing the expression of the proinflammatory cytokine tumor necrosis factor-alpha (TNF) and increasing the expression of the anti-inflammatory cytokine interleukin 10 (IL-10)

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They can provide metabolic and energy support, but they are not designed to replace nutrition and physical activity