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Highlighting glycines role in sleep regulation, non-ketotic hyperglycinemia is a rare metabolic disorder characterized by excessive levels of glycine in the blood, with sleepiness as a main symptom (Ning et al

Despite promising preclinical data, clinical trials in humans are extremely limited, and the compound remains largely experimental, with ongoing research required to fully characterize pharmacokinetics, optimal dosing, long-term safety, and potential off-target effects

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B12 can mildly increase urination, potentially affecting eye pressure or blood flow to the optic nerve