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Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis

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PubChem Reference: View compound profile on NIH PubChem Key Characteristics MOLECULAR PROFILE Formula: C 78 H 123 N 23 O 23 S 2 Weight: 1815.12 g/mol CAS: 221231-10-3 Origin: hGH 177-191 + N-terminal tyrosine Structure: Modified peptide with disulfide bridge PHYSICAL PROPERTIES Form: White to off-white lyophilized powder Solubility: Readily soluble in water Stability: Excellent with disulfide bridge Storage: Keep refrigerated 3646 F (28 C)

Sepp1UF forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1

The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2(/), but not in cyclooxygenase-1(/) mice