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Supernatant was taken from HepG2 and HepG2 ATP7B-KO cells treated with CuCl 2 (0, 0.2, 0.6mmol/l) for 24 h

The substrates for peroxidation reactions during ferroptosis are phospholipids with polyunsaturated fatty acid tails (PL-PUFAs), as they inherently possess intrinsic susceptibility to peroxidation reactions

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Amylin also helps to regulate blood sugar levels

Discussion Cx43 has multiple biological functions, including regulation of cell proliferation and differentiation, and mainly acts via gap junction intercellular communication and signal transduction 20,21,22,23,24,25,26