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We found that upregulated metabolites, such as palmitic acid, isocitric acid, methyl jasmonate, sorbitol, and spermidine, positively correlated with proinflammatory cytokines, such as IL-17 and TNF-, while they negatively correlated with various chemokines, such as IL-8, IL-12, and PDGF-bb ( Figure 6 )

The final formulation is mixed until a uniform suspension is achieved and then is filled into vials

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Once the swelling goes down and you can bear weight on the injured knee, a physical therapist will give you rehabilitative exercises

In some embodiments, the particle size of the formulation or composition described herein increases the retention time of the formulation or composition described herein