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Long-term safety data in humans is limited

5-amino-1MQ, an analogue from our initial series of NNMT inhibitors with low IC 50 value (IC 50 = ~1 M;[17]), and high cell membrane permeability (Table 2), produced the greatest reduction of intracellular 1-MNA levels at a concentration of 10 M among tested inhibitors (Figure 2D)

NNMT is overexpressed in obese adipose tissue and is theorized to deplete SAM and NAD+ pools in adipocytes, contributing to metabolic dysfunction

Its entirely possible that at least some of the symptoms we attribute to normal aging such as memory loss, cognitive decline, decreased mobility, etc

This combination was chosen to enhance dietary compatibility and improve gastrointestinal comfort