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Gastrointestinal events were the most common adverse effect, dose-related and mostly mild to moderate, eased by starting low

Cathepsin C inhibitors: property optimization and identification of a clinical candidate

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Bogo et al also observed a significant increase in daytime home cage activity in rats following an acute oral exposure to petroleum-derived JP-5, although the authors attributed this increased activity to gastric irritation

Oncology 18 , 11971202 (2009)