CB-839 (Telaglenastat), a potent, reversible, and selective small-molecule inhibitor that targets GLS-1 and has a half-maximal inhibitory concentration (IC 50 ) of 24 nM for recombinant human glutaminase C, has been investigated in solid tumors and in AML, diffuse large B-cell lymphoma, and multiple myeloma cells alone or in combination with other anticancer drugs (10, 11, 2026)
Questions to Consider Before Seeking Evaluation Before beginning any consultation process, individuals may benefit from reflecting on what specific concerns they hope to address, whether they have had relevant baseline testing, whether they are prepared for the commitment that ongoing prescription therapy entails, and whether they have conditions that might affect appropriateness
Recently, GSTM3 has been identified to exert an oncogenic or anti-tumor role in different cancers by targeting various signaling pathways
This distinction has clinical significance for safety and therapeutic consistency
In vitro and in vivo analysis of metabolites involved in the TCA cycle and glutamine metabolism associated with cisplatin resistance in human lung cancer