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Upon binding to IGF, IGF-IR undergoes changes in its conformation, which in turn abolishes the restraints of intrinsic kinase activity by the ectodomain, and triggers transphosphorylation of its tyrosine kinase domains [29]

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M., Revilla, E., Santa-Maria, C., and Vazquez, C

891,892 Overexpression of FtMt reduces ferroptosis in osteoblasts induced by high glucose, while silence FtMt induces mitochondrial autophagy through the ROS/PINK1/Parkin pathway, thereby inducing ferroptosis in osteoblasts