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Overproduction of ROS and induction of oxidative stress are major contributors to OA pathogenesis [13]

237 PerveenS.MannanS.HussainA.KanwalS

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Moreover, upregulation of Nrf2 and other antioxidant factors was detected after treatment with dexamethasone [338,339]

Selank: immunomodulatory tuftsin and anxiolytic Origin and structure Selank is a heptapeptide derived from tuftsin (Thr-Lys-Pro-Arg), an endogenous immunomodulatory fragment from IgG