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However, the accumulated data suggest that the overactivation of this signaling system could stem from inactivation or genetic ablation of the tuberous sclerosis complex (TSC) [261, 262], the master negative regulator of mTOR

This is a theoretical advantage rather than a proven one

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Autonomic neuropathy Another neuropathic complication of diabetes mellitus is cardiac autonomic neuropathy (CAN), which occurs in as many as 25% of diabetic patients (55)