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Preventive Services Task Force and 2023 American Cancer Society guidelines

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As the bacteria feed on plaque, they release acids that damage the gum tissue

We think that while it is clear that different endpoints may yield quite different results, the human MOE for cannabis based on the endpoint psychotropic effects can be seen as general validation of the MOE concept, because the resulting values below 1 are expected as the psychotropic effect is the desired endpoint (and hence the psychotropic threshold dose is exceeded by drug users)