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Because nicotine is a pharmacologically active substance and our acceptance criteria are based on relevant safety considerations, the ICH qualification thresholds for new drug products were considered appropriate for establishing acceptable limits for nicotine degradants and impurities

MTL devices with higher nicotine (including nic salts) often work well for new switchers

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In addition, they wrote, sales data might not reflect actual consumption, because all purchased products might not be used by the consumer because of loss, damage, or tobacco cessation. And because per person estimates of tobacco consumption are not exact, the authors point out that an upward trend in tobacco consumption does not necessarily mean that more Americans are using tobacco products

Several auditioned, some without knowing they were auditioning