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Free Radical Biol Med 2002;33:1290300

Furthermore, due to its chemical instability in blood and inherent light instability during storage [98,99,100], fumagillin necessitates compensatory administration of higher nanoparticle doses, which collectively compromise the intended site-specific drug delivery benefits while increasing the likelihood of off-target effects

The persistence of effects without continuous receptor occupation suggests DSIP may trigger gene expression changes rather than requiring constant pharmacological presence

Marsili, A