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Linear epitopes are continuous amino acid sequences, while conformational epitopes are composed of discontinuous sequences that fold together through the proteins three-dimensional structure [114]

Screening for Barretts esophagus The American College of Gastroenterology says screening may be recommended for men who have had GERD symptoms at least weekly that dont respond to treatment with proton pump inhibitor medication, and who have at least two more risk factors, including Having a family history of Barretts esophagus or esophageal cancer Being male Being white Being over 50 Being a current or past smoker Having a lot of abdominal fat While women are significantly less likely to have Barretts esophagus, women should be screened if they have uncontrolled reflux or have other risk factors

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