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Anti-Tumor Effects : Early studies suggest it may suppress tumor-promoting genes and reduce cancer risk

doi: 10.1046/j.1365-2346.2000.00640.x [DOI] [PubMed] [Google Scholar] 54.Sharkey RA, Mulloy EM, ONeill SJ

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This metabolic sensing function extends to regulation of key metabolic enzymes such as pyruvate dehydrogenase kinase, which is inhibited by low NAD+/NADH ratios, and lactate dehydrogenase, which is activated by high NADH levels, demonstrating the sophisticated regulatory networks that depend on NAD+ redox status