125 LamMHWingYKYuMWLeungCMMaRCKongAPet al
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Paracrine factors such as IGF-1, HGF and VEGF directly activate PI3KAkt and inhibit intrinsic apoptosis [27], while exosomal miR-21, miR-144-3p and miR-126 down-regulate PTEN , MAP3K9 and other DDR amplifiers, reinstating controlled follicle activation and reducing oxidative phosphorylation overload [21, 25, 62]
When DAO activity is low, histamine from aged, fermented, processed or poorly stored foods may accumulate and trigger symptoms
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