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For a target organ as accessible from the outside as the skin, routing a copper complex through the whole body to reach it is arguably the least efficient and highest-exposure way to do it

95% CI, -0.17-0.24

In addition, angiopoietin 2 and placental growth factor , which are associated with tumor angiogenesis, induce macrophage polarization toward the M2 phenotype, thereby leading to the development of an immunosuppressive TME 72

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This can be countered by following a programme consisting of an anti-inflammatory diet and cosmeceuticals