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The primary sites of DAO production include: Gastrointestinal tract: DAO is mainly synthesized and secreted by specialized cells in the intestinal mucosa, particularly in the small intestine, where it plays a crucial role in breaking down histamine in ingested food

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But there are studies that show that if you take lots and lots of certain probiotics like lactobacillus, and you really ramp up the levels more, it is not a case of more is better

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