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Weeks 1 and 2: introduction phase Begin with 7.5 to 10 units daily (1.5 to 2.0mg total)

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Similarly, activating the Nrf2/HO-1 axis to enhance cellular antioxidant gene expression can hamper ferroptosis, although the potentially excessive iron release from high HO-1 expression must be considered (128)

Tavassoly O, Yue J, Vocadlo DJ

Hence, Cu-based materials promote a chondrogenic microenvironment in articular cartilage after the clearance of senescent chondrocytes