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Lipoxygenase-mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3

Alleles such as s4519482 (DLX1) and rs743605 (DLX2) show significant over-transmission in ASD families, with a stronger combined risk effect (114)

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The hepatotoxicity associated with acetaminophen is primarily due to the formation of a reactive metabolite, N-acetyl-p-benzoquinoneimine (NAPQI), which induces oxidative stress and cellular damage in susceptible species, including dogs, cats, non-human primates, ferrets, birds, and pigs (Ben-Shachar et al., 2012)