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Models with only one constraint for example, normal NAD+ but low AMPK may respond adequately to MOTS-c alone, making the stack unnecessary

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Common causes include inadequate dietary intake, particularly in those following strict vegetarian or vegan diets that exclude meat, eggs, and dairythe primary sources of B12

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Additionally, chronic conditions such as HIV and tuberculosis have been implicated in B12 deficiency due to increased metabolic demand and altered absorption mechanisms (Green, 2017)