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Notably, with the rapid development of nasal delivery systems, their unique advantage of bypassing the peripheral blood circulation via the olfactory bulb pathway offers an innovative approach to overcoming the physical limitations of the blood-brain barrier and avoiding the first-pass effect in the liver, potentially becoming a key direction for optimizing brain-targeted delivery efficacy in future research [41,42,43]

maximum injection time: 200 ms

Density gradient centrifugation was used for enzymatic digestion method, while a combination of size exclusion chromatography (SEC) and sucrose cushions was used for tissue culture

Management of acute hepatitis Acute Hepatitis Autoimmune Hepatitis is typically supportive

Documented medical necessity