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16 SIRT1 is broadly expressed in metabolically active tissues 17 and regulates lipid metabolism, 18 mitochondrial maintenance, ROS clearance, autophagy, and immune balance by deacetylating key transcriptional regulators, including peroxisome proliferator-activated receptor gamma coactivator 1- (PGC-1), Forkhead Box O (FOXO), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) and p53

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Valproate-induced hepatic failure in a case of cytochrome c oxidase deficiency

Notably, induction of HO-1 expression alleviated diabetic neuropathic pain and facilitated modulation of the diabetic nerve functions [61, 62]