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At low doses, nicotine may have different neurochemical impacts, including potential antidepressant effects, while high doses can be toxic and cause severe adverse effects such as nausea, vomiting, respiratory paralysis, seizures, and even death
but, overall most leaves will have at least one hole making it a binder grade
PDF Version 2006: Tobacco Dependence: Global Public Health Potential for New Medications Development and Indications The marketing of a mint-flavored form of nicotine gum in the United States increased the market for nicotine gum by more than 25% and contributed to increasing numbers of smokers finding a treatment that was acceptable and thereby successfully quitting smoking
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